The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of Eperisone Hydrochloride (EPE) and Lornoxicam (LOR) in combined dosage forms. The method is based on the simultaneous equations for analysis of both the drugs using methanol as solvent. EPE has absorbance maxima at 255 nm and LOR has absorbance maxima at 288 nm in methanol. EPE (r2=0.999) and LOR (r2=0.995) showed linearity in the range of 2-30 µg/ml (both).The concentrations of the drugs were determined by using simultaneous equations at both the wavelengths. The mean recovery was 99.5±0.26 and 99.87±0.35 for EPE and LOR, respectively. The method was successfully applied to the assay of the drugs in synthetic mixture, which were found in the range of 101.27% & 101.36% of the labeled value for both, Eperisone Hydrochloride and Lornoxicam, respectively. The suitability of this method for the quantitative determination of EPE and LOR was proved by validation. The proposed method was found to be simple and sensitive for the routine quality control application of EPE and LOR in combination. The results of analysis have been validated statistically and by recovery studies.
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